Small molecules and methods of reducing injuries caused by radiation or chemicals
Assignee21st Century Therapeutics, Inc.
InventorJiajiu Shaw
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Abstract
A series of small molecule, radioprotective agents based on a compound of the general formula (I): or pharmaceutically acceptable salts thereof, wherein n is 1 or 2, and, independently, R is Br, Cl, H—O, H3C—S, and use of the compounds to protect healthy tissue/organs of subjects to reduce the injuries caused by radiation or chemicals.
Claims15
A method of protecting healthy living tissues/organs of a subject from radiation-induced injuries, which injuries are induced by localized radiotherapy applied to a cancer patient for treatment of cancer, said method comprising administration of a pharmaceutically acceptable salt of a compound of formula (I)
- wherein n is 1 or 2, and, independently, R is Br, Cl, H—O, H3C—S,
A method of protecting healthy living tissues or organs of a subject from chemical-induced injuries, which injuries are induced by chemotherapy, said method comprising administration of a pharmaceutically acceptable salt of a compound of formula (I)
- wherein n is 1 or 2, and, independently, R is Br, Cl, H—O, H3C—S,
A method of protecting healthy living tissues/organs of a subject from radiation-induced injuries, which injuries are induced by total-body irradiation or localized radiotherapy of a cancer patient subject for therapeutic purpose or applied to a subject exposed to non-medical radiation resulting from terrorism, nuclear war or accidental exposure, said method comprising administration of a pharmaceutically acceptable salt of a compound of formula (I)
- wherein n is 1 or 2, and, independently, R is Br, Cl, H—O, H3C—S,
A method of protecting healthy living tissues/organs of a subject from radiation-induced or chemical-induced injuries which method comprises administration of a compound of formula (I)
- or pharmaceutically acceptable salt thereof, wherein n is 1 or 2, and, independently, R is Br, Cl, H—O or
A method of protecting healthy living tissues/organs of a subject from radiation-induced or chemical-induced injuries which method comprises administration of a compound of formula (I)
- or pharmaceutically acceptable salt thereof, wherein n is 2 and, independently, R is Br, Cl, H—O, H3C—S,
Dependencies are inferred from the claim text.