Substituted sulfoximine compounds

A compound having the structure of general formula (I)

• wherein
• ‘A’ is selected from unsubstituted or substituted (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C6)cycloalkyl, aryl, heteroaryl and heterocyclyl groups having optionally one or more than one heteroatom;
• ‘B’ is the following ring system
• wherein X, Y, Z at each occurrence is independently selected from C, N, S, SO2, and O, which may be optionally substituted;
• n=0-3;
• R1 at each occurrence independently represents hydrogen, halogen, haloalkyl, cyano, optionally substituted groups selected from (C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)alkoxy, (C3-C6)cycloalkyl, aryl, heteroaryl, heterocyclyl, benzyl, mercapto alkyl, sulfur and its oxidized forms;
• when A represents a ring, R1 may additionally represent thiol, sulfur and its oxidized forms, C1-C6(thio-alkoxy), bridged or spiro ring system having optionally one or more than one heteroatom;
• R2 at each occurrence independently represents hydrogen, halide, cyano, optionally substituted groups selected from (C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)alkoxy (C3-C6)cycloalkyl, benzyl, aryl, heteroaryl, heterocyclyl, thiol, thioalkyl, thio-alkoxy sulfur and its oxidized forms, bridged or spiro ring system having optionally one or more than one heteroatom;
• R3 at each occurrence independently represents hydrogen, hydroxyl, halogen, nitro, cyano, optionally substituted groups selected from (C1-C10)alkyl, (C1-C10)alkoxy, (C3-C10)cycloalkyl, (C2-C10)alkenyl, (C2-C10)alkynyl, SO2(C1-C6)alkyl, benzyl, aryl, heteroaryl, heterocyclyl, thiol, thioalkyl, thio-alkoxy, sulfur and its oxidized forms, or R3 and A together with the atom to which they are attached may form an optionally substituted 5 to 7 membered heterocyclic ring system having optionally one or more than one heteroatom;
• ‘m’ represents an integer from 1-5;
• R4 at each occurrence is independently selected from hydrogen, halogen, cyano, amide, sulphonamide, acyl, hydroxyl, optionally substituted groups selected from (C1-C6)alkyl, (C1-C6)haloalkyl, (C3-C6)cycloalkyl, and (C1-C6)alkoxy;
• wherein the substitutions on any of the optionally substituted groups above are independently selected from hydrogen, hydroxy, cyano, halo, haloalkyl, haloalkyloxy, alkylthio (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C10)cycloalkyl, C1-C6alkoxy, —COR10, —CSR10, C(O)OR10, C(O)—R10, —C(O)—NR11R12, —C(S)—NR11R12, —SO2R10 group, wherein R10 is independently selected from hydrogen, optionally substituted group selected from (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C7)cycloalkyl, aryl, heteroaryl, and heterocyclyl group;
• each of R11 and R12 are independently selected from hydrogen, optionally substituted group selected from (C1-C6)alkyl, (C1-C6)alkoxy, aryl and benzyl group.