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US 11,236,044 B2Granted
Selective inhibitors of 12(S)-lipoxygenase (12-LOX) and methods for use of the same
AssigneeThe Regents of the University of Michigan
InventorsMichael Holinstat, Reheman Adili, Andrew White
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Abstract
Disclosed herein are small molecule inhibitors of 12(S)-Lipoxygenase (12-LOX), and methods of using the small molecules to inhibit 12-LOX activation and to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
Claims20
A compound of Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- R2 is halo, C1-3fluoroalkyl, C3-8fluorocyloalkyl, OC1-3fluoroalkyl, or OC3-8fluorocyloalkyl;
- each of R1, R3, R4, and R5 independently is H, halo, C1-3fluoroalkyl, C3-8fluorocyloalkyl, OC1-3fluoroalkyl, or OC3-8fluorocyloalkyl;
- each of Ra and Rb independently is OH, OC1-3alkyl, C1-3fluoroalkyl, C3-8fluorocyloalkyl, OC1-3fluoroalkyl, OC3-8fluorocyloalkyl, or halo;
- and
- each of Rc, Rd, and Re independently is H, OH, OC1-3alkyl, C1-3fluoroalkyl, C3-8fluorocycloalkyl, OC1-3fluoroalkyl, OC3-8fluorocyloalkyl, or halo.
3 more elements
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.