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US 11,235,328 B2Granted
Coplanar microfluidic manipulation
AssigneeHewlett-Packard Development Company, L.P.
InventorsMichael W. Cumbie, Viktor Shkolnikov, Chien-Hua Chen
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Abstract
An apparatus includes a polymer base layer having a surface. A die that includes a fluid manipulation surface that is substantially coplanar with the surface of the polymer base layer. The die includes a control electrode to generate an electric field to perform microfluidic manipulation of fluid across the fluid manipulation surface of the die.
Claims14
An apparatus, comprising
- a polymer base layer having a surface;
- and
- an integrated die having a fluid manipulation surface that is substantially coplanar with the surface of the polymer base layer, wherein no impediment to fluid flow is present at a juncture between the surface of the polymer base layer and the integrated die, and from an interconnect formed between an input/output port and the die, and wherein the polymer base layer and the integrated die form a coplanar fluid manipulation surface, and wherein the integrated die includes a control electrode configured to generate an electric field to perform microfluidic manipulation of fluid across the coplanar fluid manipulation surface of the integrated die and the polymer base;
- and
- a reagent storage package directly coupled to the polymer base layer, wherein the reagent storage package is configured to release a reagent therefrom.
2 more elements
An apparatus, comprising:
- a polymer base layer having a surface;
- an integrated die having a fluid manipulation surface that is substantially coplanar with a surface of the polymer base layer, wherein no impediment to fluid flow is present at a juncture between the polymer base layer and the integrated die, and from an interconnect formed between an input/output port and the die, and wherein the polymer base layer and the integrated die form a coplanar fluid manipulation surface, and wherein the integrated die includes a control electrode configured to generate an electric field to perform manipulation of fluid across the coplanar fluid manipulation surface of the polymer base layer and the integrated die;
- and
- a fluidic transport layer supported by the polymer base layer and comprising a fluidic channel fluidly coupled with a fluidic input/output (I/O) port, the fluidic channel extends longitudinally across the fluidic transport layer from the die to the I/O port to space the I/O port apart from the fluid manipulation surface of the die;
- and
- a reagent storage package coupled to a reagent layer, wherein the reagent layer is coupled to the polymer base layer, and wherein the reagent storage package is configured to release a reagent therefrom.
3 more elements
A method, comprising:
- joining an integrated die to a polymer base layer, the integrated die including a control electrode at a fluid manipulation surface of the integrated die to generate an electric field to perform microfluidic manipulation of fluid across the fluid manipulation surface of the integrated die, a distal portion of the integrated die extending from the fluid manipulation surface of the integrated die into the polymer base layer such that the fluid manipulation surface of the integrated die remains exposed and substantially coplanar with an exposed adjacent surface of the polymer base layer, wherein no impediment to fluid flow is present at a juncture between the polymer base layer and the integrated die, and from an interconnect formed between an input/output port and the die, and wherein the polymer base layer and the integrated die form a coplanar fluid manipulation surface;
- and
- forming a fluidic transport layer on a portion of the exposed surfaces of the polymer base layer and the integrated die, the fluidic transport layer comprising a fluidic channel and an input/output (I/O) port, the fluidic channel fluidly coupling the I/O port and the fluid manipulation surface of the integrated die.
Dependencies are inferred from the claim text.