Catalysts for chemical reactions in a water-surfactant mixture
AssigneeNovartis AG
InventorsFabrice Gallou, Pengfei Guo, Jianguang Zhou, Michael Parmentier
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Abstract
The present invention is directed to reaction mixtures comprising a water-surfactant mixture, wherein the catalyst comprises a compound with solubilizing groups. This technology improves the solubility of the reaction components in the water-surfactant mixture and thereby, greatly increases the productivity and selectivity of the chemical reaction.
Claims18
A reaction mixture comprising one or more reactants, a catalyst and a surfactant-water mixture, wherein the catalyst is
- a coupling reagent, wherein the coupling reagent is a 1,3,5-triazine comprising one or more solubilizing groups;
- wherein the solubilizing group comprises a C5-50 alkyl group or a poly(alkylene glycol) group with 2 to 20 repeating units,
- wherein the surfactant-water mixture comprises a surfactant and water, and the surfactant is DL-α-Tocopherol methoxypolyethylene glycol succinate.
A method of increasing a yield of a chemical reaction performed in a surfactant-water mixture, comprising the steps of
- (a) providing a reaction mixture comprising one or more reactants, a catalyst, and a surfactant-water mixture, wherein the catalyst is
- a coupling reagent, wherein the coupling reagent is a 1,3,5-triazine comprising one or more solubilizing groups,
- wherein the solubilizing group comprises a C5-50 alkyl group or a poly(alkylene glycol) group with 2 to 20 repeating units,
- wherein the surfactant-water mixture comprises a surfactant and water, and the surfactant is DL-α-Tocopherol methoxypolyethylene glycol succinate;
- and
- (b) allowing the chemical reaction to proceed.
A method of decreasing an amount of side products produced in a chemical reaction performed in a surfactant-water mixture, comprising the steps of
- (a) providing a reaction mixture comprising one or more reactants, a catalyst, and a surfactant-water mixture, wherein the catalyst is
- a coupling reagent, wherein the coupling reagent is a 1,3,5-triazine comprising one or more solubilizing groups;
- wherein the solubilizing group comprises a C5-50 alkyl group or a poly(alkylene glycol) group with 2 to 20 repeating units,
- wherein the surfactant-water mixture comprises a surfactant and water, and the surfactant is DL-α-Tocopherol methoxypolyethylene glycol succinate;
- and
- (b) allowing the chemical reaction to proceed.
Dependencies are inferred from the claim text.