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US 11,235,068 B2Granted
Cyclodextrin-panobinostat adduct
AssigneeMidatech Limited
InventorsTom Coulter, Stephen Damment, Alessandro Pace, Daniel Palmer
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AssigneeMidatech Limited
InventorsTom Coulter, Stephen Damment, Alessandro Pace, Daniel Palmer
Estimating the term…
The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.
A method of treatment of a brain tumour in a mammalian subject, comprising administering a therapeutically effective amount of a cyclodextrin-panobinostat adduct to a mammalian subject in need thereof, wherein the cyclodextrin-panobinostat adduct is administered at a concentration of between 1 μM and 100 μM.
A method of treatment of a brain tumour in a mammalian subject, comprising administering a therapeutically effective amount of a cyclodextrin-panobinostat adduct to a mammalian subject in need thereof, wherein the cyclodextrin-panobinostat adduct is administered at a concentration of between 1 μM and 100 μM, and wherein the method comprises administration via convection-enhanced delivery (CED).
Dependencies are inferred from the claim text.