Primed muscle progenitor cells and uses thereof
AssigneePurdue Research Foundation
InventorStacey L. Halum
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Abstract
This invention relates to a method for repairing and reconstructing a damaged or non-functional muscle, in particular to a method and a tool kit using in vitro primed motor endplate-expressing muscle progenitor cells (MPCs) to promote innervation of the damaged or non-functional muscle using an agent without any genetic manipulation. This method is particularly useful for repairing or reconstructing damaged or non-functional head and neck muscles, and urinary detrusor bladder muscle.
Claims9
A method of cell therapy without any artificial supporting scaffolds for repairing or reconstructing a damaged or non-functioning muscle of a patient with enhanced innervation comprising the steps of:
- a. acquiring a plurality of motor endplate-expressing muscle progenitor cells (MPCs) from a patient with a damaged muscle;
- b. priming acquired MPCs by incubating said MPCs in the presence of an agent selected from the group consisting of acetylcholine, neuregulin, agrin, and a combination thereof;
- and
- c. introducing the primed MPCs to the damaged muscle of said patient through minimally invasive, non-surgery injection directly to the site of damaged muscle.
Dependencies are inferred from the claim text.