Molecular origin of allergy
AssigneeGenclis
InventorsBernard Bihain, Virginie Ogier, Marie Brulliard, Sandrine Jacquenet, Benoit Thouvenot, Olivier Roitel
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Abstract
The present invention relates to compositions and methods for modulating or detecting allergy in a subject. The invention may be used to reduce allergenicity of compositions, such as food products, or to stimulate immunogenicity of products, such as vaccines by removal of cationic proteins resulting from transcription infidelity. The invention may be used in any mammal such as human.
Claims18
A method for reducing immunogenicity or allergenicity of a composition, the method comprising treating the composition to remove cationic proteins, wherein the removed cationic proteins comprise proteins resulting from transcription infidelity.
A method for preparing a food product comprising (i) providing a food product preparation containing cationic proteins, (ii) treating the food product preparation to remove cationic proteins comprising proteins resulting from transcription infidelity, and (iii) optionally formulating the treated food product with one or more suitable excipients.
A method for preparing a pharmaceutical product comprising (i) providing a pharmaceutical product preparation, (ii) treating the pharmaceutical product preparation to remove cationic proteins comprising proteins resulting from transcription infidelity, and (iii) optionally formulating the treated pharmaceutical product with one or more suitable excipients.
A method for reducing immunogenicity or allergenicity of a composition, the method comprising treating the composition to remove cationic proteins, and wherein the method comprises (i) providing a solution of the composition, (ii) adjusting, if necessary, the solution of the composition to have a pH between 7 and 9, (iii) subjecting the solution to cation exchange chromatography allowing binding of components of the solution having an isoelectric point above the adjusted pH, (iv) recovering the unbound flow-through, and (v) subjecting the flow-through to affinity chromatography using transcription infidelity antibodies.
A method for reducing immunogenicity or allergenicity of a composition, the method comprising treating the composition to remove cationic proteins, wherein the composition comprises milk or a dairy product and the method comprises removing at least one protein comprising a transcription infidelity peptide sequence selected from SEQ ID NO:
- 1 to 5.
Dependencies are inferred from the claim text.