Systems and methods for medical image registration

A computer implemented method for adapting a registration between 2D intravital anatomical imaging modality image data and 3D nuclear medicine image data of a heart of a patient, comprising:

• obtaining a registered image generated between 2D intravital anatomical imaging modality image data captured by at least one of a fluoroscopy machine and a 2D x-ray machine and 3D nuclear medicine image data of a heart of a patient, the registered image including a segmentation of a network of vessels of the heart,
• wherein the anatomical 2D image data includes at least two 2D anatomical images captured from two or more different viewing angles of the heart of the patient by at least one of the fluoroscopy machine and the 2D x-ray machine,
• wherein the registered image is computed by correlating segmentation of the network of vessels of the heart obtained from the 2D images captured from two or more different viewing angles by the at least one of a fluoroscopy machine and a 2D x-ray machine, and a correlated contour obtained from the 3D nuclear medicine image data;
• identifying at least one manual user input indicative of at least one un-segmented vessel within the registered image;
• and
• adapting the registered image to include the at least one un-segmented vessel as part of the segmented vessel network, based on the at least one manual user input acting as at least one seed point grown towards the segmented vessel network.

A system for registration of 2D intravital anatomical imaging modality image data and 3D nuclear medicine image data of a heart of a patient, comprising:

• a central server comprising:
• an anatomical interface configured to obtain 2D anatomical image data captured by at least one of a fluoroscopy machine and a 2D x-ray machine, the 2D anatomical image data including a heart of a patient;
• wherein the anatomical 2D image data includes at least two 2D anatomical images captured from two or more differing viewing angles of the heart of the patient by at least one of the fluoroscopy machine and the 2D x-ray machine;
• a nuclear medicine interface configured to obtain at least one 3D nuclear medicine image data outputted by a nuclear medicine imaging modality, the at least one 3D nuclear medicine image including the heart of the patient;
• a hardware processor;
• a memory in communication with the processor, the memory having stored thereon code instruction for execution by the processor, including:
• code to identify a segmentation of a network of vessels of the heart in the 2D anatomical image data;
• code to identify a contour of at least part of the heart in the at least one 3D nuclear medicine image, the contour including at least one muscle wall border of the heart;
• code to correlate between the segmentation obtained from the 2D images captured from two or more different viewing angles by the at least one of a fluoroscopy machine and a 2D x-ray machine, and the contour obtained from the 3D nuclear medicine image data;
• code to register the correlated segmentation obtained from the 2D images captured from two or more different viewing angles by the at least one of a fluoroscopy machine and a 2D x-ray machine, and the correlated contour obtained from the 3D nuclear medicine image data to form a registered image;
• and
• an output interface configured to provide the registered image for display.