Back to results
US 11,231,429 B2Granted
Cardiovascular risk evaluations using a risk parameter that includes an HDL and inflammatory biomarker interaction parameter
AssigneeLipoScience, Inc.
InventorsJames D. Otvos, Irina Y. Shalaurova
Life of this patent
Estimating the term…
Abstract
Methods, systems and circuits evaluate a subject's CVD risk using a risk parameter that includes at least one HDL and inflammatory biomarker interaction parameter. The inflammatory biomarker may optionally comprise NMR derived measurements of GlycA from at least one biosample of the subject. The risk parameter may be gender-specific.
Claims11
A computer program product for determining a risk parameter for cardiovascular disease or events according to the method of:
- using a Nuclear Magnetic Resonance spectrometer to obtain measurements of HDL particles and inflammatory biomarker GlycA on a biosample from a subject;
- determining NMR-derived concentrations for at least one individual HDL particle size subclass and the inflammatory biomarker GlycA, based on the measurements;
- programmatically calculating a risk parameter ((HxI)CVD) of the subject using at least the concentrations for the at least one individual HDL particle size subclass and the inflammatory biomarker GlycA;
- and
- determining a subject's risk of having and/or developing CVD based, at least in part, on the (HxI)CVD risk parameter number.
2 more elements
A computer program product for determining a risk parameter for cardiovascular disease or events, the computer program product comprising:
- a non-transitory computer readable storage medium having computer readable program code embodied in the medium, the computer readable program code comprising:
- computer readable program code that obtains concentration measurements from a Nuclear Magnetic Resonance spectrometer for at least eight subclasses of HDL-P in a blood plasma or serum sample and for inflammatory biomarker GlycA;
- and
- computer readable program code that calculates a risk parameter ((HxI)CVD) comprising at least one interaction parameter defined by the concentration of GlycA multiplied by the concentration of one or more of the at least eight subclasses of HDL-P.
1 more element
Dependencies are inferred from the claim text.