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US 11,231,420 B2Granted
Selection and optimization of aptamers to recognize ebola markers
AssigneeAptalogic, Inc.
InventorsSoma Banerjee, Marit Nilsen-Hamilton
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Abstract
Aptamers have been identified that bind to the sGP protein in ebola virus. The aptamers are single stranded DNA aptamers. The aptamers have high specificity and bind sGP in serum samples. The aptamers can be used to detect infection of individuals with ebola virus. Methods for detecting ebola virus in an individual are disclosed.
Claims16
An aptamer comprising a DNA sequence, wherein the DNA sequence is SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16 and/or SEQ ID NO:
- 17, wherein the aptamer is capable of binding to a marker of ebola virus and wherein the marker is a protein produced from the glycoprotein (GP) gene.
1 more element
A nucleic acid compound comprising a DNA sequence with at least 80% identity to SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16 and/or SEQ ID NO:
- 17.
1 more element
A kit comprising an aptamer, wherein the aptamer comprises a DNA sequence, wherein the DNA sequence is SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16 and/or SEQ ID NO:
- 17 and wherein the aptamer binds to sGP of ebola virus.
1 more element
Dependencies are inferred from the claim text.