Surrogate biomarker for evaluating intracerebral amyloid ß peptide accumulation and method for analysis thereof

Abstract

Provided are a biomarker for evaluating a cerebral Aβ accumulation state using an amyloid precursor protein (APP)-derived peptide in a living body-derived sample as an index, and a method for analysis thereof. A living body-derived sample derived from a test subject is measured, and at least one ratio selected from the group consisting of APP669-711/APP672-713 (Aβ1-42); APP672-709 (Aβ1-38)/APP672-713 (Aβ1-42); APP674-711 (Aβ3-40)/APP672-713 (Aβ1-42); APP672-710 (Aβ1-39)/APP672-713 (Aβ1-42); APP672-711 (Aβ1-40)/APP672-713 (Aβ1-42); and APP672-711 (OxAβ1-40)/APP672-713 (Aβ1-42) is calculated, and when each of the ratios of the test subject is higher than each of standard levels which are ratios of a person having normal cognitive function NC− who is negative for cerebral Aβ accumulation, an accumulation amount of cerebral Aβ of the test subject is determined as larger than an accumulation amount of cerebral Aβ of the person having normal cognitive function NC−.

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