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US 11,231,401 B2Granted
Methods for detecting chromogranin a by mass spectrometry
AssigneeQuest Diagnostics Investments Incorporated
InventorsDarren Weber, Michael P. Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
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Abstract
Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
Claims30
A method for determining the amount of chromogranin A (CgA) in a sample, said method comprising:
- (a) purifying CgA in the sample;
- (b) ionizing CgA to produce one or more ion(s) of CgA detectable by mass spectrometry;
- (c) determining the amount of the ion(s) from step (b) by mass spectrometry, comprising quantifying the amount of fragment ion having a mass-to-charge ratio of 831.5±0.5 or 989.5±0.5,
- wherein the amount of ions quantified in step (c) is related to the amount of CgA in the sample.
1 more element
Dependencies are inferred from the claim text.