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US 11,230,703 B2Granted
Recombinant microorganism and method for production of formic acid by using same
AssigneeUnist (Ulsan National Institute of Science and Technology)
InventorsYong Hwan Kim, Jung Ho Jang, Byoung Wook Jeon
Life of this patent
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Abstract
The present invention relates to a recombinant microorganism for producing formic acid, which has a formate dehydrogenase 1 alpha subunit (FDH1α)-encoding endogenous gene deleted therefrom and an FDH1-encoding exogenous gene introduced thereinto, and a method for production of formic acid by using the microorganism.
Claims15
A recombinant microorganism comprising a genetic modification that increases production of formate, wherein the genetic modification comprises:
- a deletion of an endogenous gene encoding formate dehydrogenase 1 alpha subunit (FDH1α) and an introduction of an exogenous gene encoding a homologous formate dehydrogenase 1 (FDH1),
- wherein the recombinant microorganism is modified from a microorganism of the genus Methylobacterium, and the microorganism of the genus Methylobacterium produces formate,
- wherein the microorganism of the genus Methylobacterium is selected from the group consisting of M. adhaesivum, M. chloromethanicum, M. suomiense, M. platani, M. soli, and M. extorquens.
Dependencies are inferred from the claim text.