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US 11,230,702 B2Granted
Blood brain barrier model and methods of making and using the same
AssigneeWake Forest University Health Sciences
InventorsRobert T. Wicks, Anthony Atala, Goodwell Nzou, Elizabeth E. Wicks
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Abstract
Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.
Claims24
An in vitro model of a blood brain barrier, said model comprising:
- (a) an endothelial cell layer comprising astrocytes, pericytes and endothelial cells, and optionally smooth muscle cells;
- and
- (b) a neuronal cell layer comprising neuronal cells, and optionally oligodendrocytes and/or microglia,
- wherein said in vitro model further comprises a porous membrane between said endothelial cell layer and said neuronal cell layer.
1 more element
Dependencies are inferred from the claim text.