Cytokine receptor genes and the use thereof to enhance therapy
AssigneeMUSC Foundation for Research Development
InventorsMark Rubinstein, David Cole
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Abstract
Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.
Claims17
An isolated transgenic human immune cell comprising a recombinant vector comprising a sequence encoding at least one cytokine receptor polypeptide, wherein the cytokine receptor is IL-2.
A method treating a subject having cancer comprising administering an amount of transgenic human immune cells comprising a recombinant vector comprising a sequence encoding at least one cytokine receptor polypeptide, wherein the cytokine receptor is IL-2 effective to treat said cancer.
Dependencies are inferred from the claim text.