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US 11,230,605 B2Granted
Anti-TfR antibodies and their use in treating proliferative and inflammatory disorders
AssigneeInatherys
InventorsPierre Launay, Coralie Belanger, Hervé Souchet
Life of this patent
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Abstract
The present invention relates to humanized antibodies that specifically bind to human transferrin receptor and their use in treating cancer and inflammatory disorders.
Claims17
An isolated anti-transferrin receptor (TfR) antibody or a protein comprising an antigen-binding portion thereof, comprising either,
- (a) a variable heavy chain polypeptide comprising VH of SEQ ID NO:11 and a variable light chain polypeptide comprising VL of SEQ ID NO:13;
- (b) a variable heavy chain polypeptide comprising VH of SEQ ID NO:11 and a variable light chain polypeptide comprising VL of SEQ ID NO:14;
- (c) a variable heavy chain polypeptide comprising VH of SEQ ID NO:12 and a variable light chain polypeptide comprising VL of SEQ ID NO:13;
- or,
- (d) a variable heavy chain polypeptide comprising VH of SEQ ID NO:12 and a variable light chain polypeptide comprising VL of SEQ ID NO:14;
- wherein said anti-TfR antibody or protein comprising an antigen-binding portion thereof specifically binds to the transferrin receptor (TfR) of SEQ ID NO:16.
3 more elements
An isolated anti-transferrin receptor (TfR) antibody, comprising either,
- (a) a variable heavy chain polypeptide comprising VH of SEQ ID NO:11 and a variable light chain polypeptide comprising VL of SEQ ID NO:13;
- (b) a variable heavy chain polypeptide comprising VH of SEQ ID NO:11 and a variable light chain polypeptide comprising VL of SEQ ID NO:14;
- (c) a variable heavy chain polypeptide comprising VH of SEQ ID NO:12 and a variable light chain polypeptide comprising VL of SEQ ID NO:13;
- or,
- (d) a variable heavy chain polypeptide comprising VH of SEQ ID NO:12 and a variable light chain polypeptide comprising VL of SEQ ID NO:14.
2 more elements
Dependencies are inferred from the claim text.