Anti-GARP protein
AssigneesLudwig Institute for Cancer Research, Université Catholique De Louvain, argenx BVBA
InventorsSophie Lucas, Pierre Coulie, Julia Cuende Villasur, Laure Dumoutier, Jean-Christophe Renauld, Sebastian van der Woning, Michael Saunders, Hans De Haard, Gitte De Boeck
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Abstract
The present invention relates to a protein binding to GARP in the presence of TGF-β and uses thereof.
Claims15
An anti-human Glycoprotein A repetitions predominant (hGARP) antibody, comprising
- a heavy chain variable region comprising the following CDRs:
- VH-CDR1:
- (SEQ ID NO:
- 52)
- GYGIN;
- VH-CDR2:
- (SEQ ID NO:
- 3)
- MIWSDGSTDYNSVLTS;
- and
- VH-CDR3:
- (SEQ ID NO:
- 4)
- DRNYYDYDGAMDY.
- a light chain variable region comprising the following CDRs:
- VL-CDR1:
- (SEQ ID NO:
- 5)
- KASDHIKNWLA;
- VL-CDR2:
- (SEQ ID NO:
- 6)
- GATSLEA;
- and
- VL-CDR3:
- (SEQ ID NO:
- 7)
- QQYWSTPWT.
An antibody or antigen binding fragment produced by a hybridoma registered under the accession number LMBP 10246CB on May 30, 2013.
A hybridoma cell line producing an antibody against GARP registered under the accession number LMBP 10246CB on May 30, 2013.
Dependencies are inferred from the claim text.