Anti-galactofuranose antibodies for detecting and treating aspergillosis
AssigneesThe Royal Institution for the Advancement of Learning/Mcgill University, The Governors of the University of Alberta
InventorsDonald Christopher Sheppard, Benjamin Alfred William Rufus Ralph, Todd Lambert Lowary, Susmita Sarkar, Amira Ibrahim Aly Mohamed Khalil
Life of this patent
Estimating the term…
Abstract
It is provided novel anti-galactofuranose antibodies and their use for diagnosis of and/or treating aspergillosis, and for the design of chimeric antigen receptor T-cells, wherein single chain variable fragment of the antibodies, such as a heavy chain variable region or a light chain variable region, is fused via a spacer and a transmembrane domain to a signaling endodomain to generate an expression cassette that will be integrated into a T cell.
Claims14
An antibody or a functional fragment thereof, comprising at least one of:
- a) a heavy chain encoded by the DNA sequence consisting of SEQ ID NO:
- 5;
- b) a heavy chain amino acid sequence consisting of SEQ ID NO:
- 6;
- c) a light chain encoded by the DNA sequence consisting of SEQ ID NO:
- 7;
- d) a light chain amino acid sequence consisting of SEQ ID NO:
- 8;
- and
- e) a combination thereof.
Dependencies are inferred from the claim text.