Chimeric proteins for targeting dsRNA
AssigneeTargimmune Therapeutics AG
InventorsAlexander Levitzki, Yael Langut, Nufar Edinger
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Abstract
Described herein are recombinant chimeric proteins comprising a double stranded RNA (dsRNA) binding domain and a cancer-cell targeting domain for targeting of dsRNA to cancer cells. Methods of use of the described chimeric proteins are also provided herein.
Claims20
A recombinant protein comprising a double stranded RNA (dsRNA) binding domain and a target-binding moiety, wherein said target-binding moiety is EGF and said dsRNA binding domain comprises one or more double-stranded RNA-binding motifs (dsRBM), wherein at least one of said one or more dsRBMs is a dsRBM of dsRNA dependent protein kinase R (PKR), and wherein said recombinant protein further comprises a linker between the dsRNA binding domain and the target-binding moiety, wherein said linker is a peptide of sequence ACSGSACSGSAGNRVRRSVGSSNG (SEQ ID NO:
- 26).
Dependencies are inferred from the claim text.