Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant P53
AssigneeYeda Research and Development Co. Ltd.
InventorsVarda Rotter, Moshe Oren, Perry Tal, Shay Eizenberger, Avi Ben-Shimon
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Abstract
An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.
Claims11
An isolated peptide comprising the amino acid sequence set forth in SEQ ID NO. 429, wherein said isolated peptide has greater cytotoxicity than pCAP 250 (SEQ ID NO:
- 1) for cancer cells having mutant p53.
Dependencies are inferred from the claim text.