mTORC modulators and uses thereof

A compound represented by the structure of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from hydroxy,
• and optionally substituted heteroaryl;
• R2 is selected from hydrogen and an optionally substituted C1-C6 alkoxy group, wherein substituents are independently selected at each occurrence from hydroxy, halogen, cyano, nitro, C2-C6 alkoxy group, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl, wherein cycloalkyl, aryl, heterocyloalkyl, and heteroaryl, are each optionally substituted with one or more substituents independently selected from hydroxy, halogen, cyano, nitro, alkyl, haloalkyl, hydroxyalkyl, alkoxy, and alkoxyalkyl;
• R3 is selected from hydrogen and an optionally substituted C1-C6 alkoxy group, wherein the substituents independently selected at each occurrence from hydroxy, halogen, cyano, nitro, C2-C6 alkoxy group, cycloalkyl, aryl, heteroaryl, and heterocycloalkyl, wherein cycloalkyl, aryl, heterocyloalkyl, and heteroaryl, are each optionally substituted with one or more substituents independently selected from hydroxy, halogen, cyano, nitro, alkyl, haloalkyl, hydroxyalkyl, alkoxy, and alkoxyalkyl;
• and
• wherein the optionally substituted heteroaryl of R1 may be substituted with one or more substituents independently selected from:
• hydroxy, halogen, cyano, nitro, C1-C6 alkyl, haloalkyl, hydroxy C1-C6 alkyl, alkoxy, and alkoxy C1-C6 alkyl;
• R4 is selected from:
• R20 is selected from hydrogen and optionally substituted C1-C6 alkyl;
• R21 is selected from optionally substituted C1-C6 alkyl, and optionally substituted 3 to 7 membered heterocycle;
• R22 is selected from C2-C6 alkyl substituted with one or more substituents selected from —(O—CH2—(CH2)p)n—W and —OR30;
• R23 is selected from optionally substituted C1-C6 alkyl and optionally substituted 3 to 7-membered heterocycle;
• wherein the substituents on R20, R21, and R23 are independently selected at each occurrence from:
• halogen, —OR30, —N(R30)2, —(—CH2—(CH2)p)n—W, —SR30, —N(R30)2, —C(O)R30, —C(O)N(R30)2, —N(R30)C(O)R30, —C(O)OR30, —OC(O)R30, —S(O)R30, —S(O)2R30, —P(O)(OR30)2, —OP(O)(OR30)2, —NO2, ═O, ═S, ═N(R30), and —CN;
• C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, —OR30, —SR3°, —N(R30)2, —C(O)R30, —C(O)N(R30)2, —N(R30)C(O)R30, —C(O)OR30, —OC(O)R30, —S(O)R30, —S(O)2R30, —P(O)(OR30)2, —OP(O)(OR30)2, —NO2, ═O, ═S, ═N(R30), —CN, C3-10 carbocycle and 3- to 10-membered heterocycle;
• and
• C3-10 carbocycle and 3- to 10-membered heterocycle each of which is optionally substituted with one or more substituents independently selected from halogen, —OR30, —SR30, —N(R30)2, —C(O)R30, —C(O)N(R30)2, —N(R30)C(O)R30, —C(O)OR30, —OC(O)R30, —S(O)R30, —S(O)2R30, —P(O)(OR30)2, —OP(O)(OR30)2, —NO2, ═O, ═S, ═N(R30), —CN, C1-6 alkyl, C1-6 alkyl-R30, C2-6 alkenyl, and C2-6 alkynyl;
• each p is selected from 1 or 2;
• n is selected from 1-4;
• W is selected from —OH and —CH3;
• and
• R30 is independently selected at each occurrence from hydrogen, —Si(C1-C6 alkyl)3;
• and C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, —OH, —OSi(C1-C6 alkyl)3, —CN, —NO2, —NH2, ═O, ═S, C1-10 alkyl, —C1-10 haloalkyl, alkyl, C2-10 alkenyl, C2-10) alkynyl, C3-12 carbocycle, and 3- to 12-membered heterocycle.