Quinolino-pyrrolidin-2-one derivative and application thereof

A compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof,

• wherein,
• E is selected from —N(R5)—, —O— and —C(R6)(R7)—;
• R1 is selected from C1-3 alkyl, C1-3 alkoxy and C3-6 cycloalkyl, wherein the C1-3 alkyl, C1-3 alkoxy and C3-6 cycloalkyl are optionally substituted with 1, 2 or 3 Ra;
• R2 is selected from H, F, Cl, Br, I, OH and NH2;
• R3 is selected from H, F, Cl, Br, I, OH, NH2, CN, C1-3 alkyl and C1-3 alkoxy, wherein the C1-3 alkyl and C1-3 alkoxy are optionally substituted with 1, 2 or 3 Rb;
• R4 is selected from C1-6 alkyl and N(Rc)(Rd);
• R5 is selected from H, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkyl-C═O—, C1-6 alkyl-O—C═O— and C3-6 cycloalkyl-C═O—, wherein the C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkyl-C═O—, C1-6 alkyl-O—C═O— and C3-6 cycloalkyl-C═O— are optionally substituted with 1, 2 or 3 Re;
• R6 and R7 are each independently selected from H, F, Cl, Br, I, OH, NH2, CN, C1-6 alkyl and C1-6 alkoxy, wherein the C1-6 alkyl or C1-6 alkoxy are optionally substituted with 1, 2 or 3 Rf;
• L1 is selected from a single bond, —(CH2)m— and —(CH2)m—O—;
• m is selected from 1, 2, 3 and 4;
• ring B is selected from phenyl and 5- to 6-membered heteroaryl, wherein the phenyl and 5-to 6-membered heteroaryl are optionally substituted with 1, 2 or 3 Rg;
• Ra and Rb are each independently selected from F, Cl, Br, I, OH and NH2;
• Rc and Rd are each independently selected from H, C1-3 alkyl and C3-6 cycloalkyl, wherein the C1-3 alkyl and C3-6 cycloalkyl are each independently selected from 1, 2 or 3 R;
• or, Rc and Rd together with the N atom to which they are attached form 4- to 6-membered heterocycloalkyl optionally substituted by 1, 2 or 3 R;
• Re, Rf and Rg are each independently selected from F, Cl, Br, I, OH and NH2;
• Each R is independently selected from F, Cl, Br, I, OH and NH2;
• and the 5- to 6-membered heteroaryl and 4- to 6-membered heterocycloalkyl are each independently comprise 1, 2, 3 or 4 heteroatoms or heteroatom groups independently selected from —NH—, —O—, —S— and N.