Substituted 1,3,4-thiadiazoles as GLS1 inhibitors

A compound of formula (I):

• or a pharmaceutically acceptable salt or stereoisomer thereof,
• wherein:
• ring A is 5- to 10-membered heteroaryl, wherein the 5- to 10-membered heteroaryl contains 1, 2, 3, or 4 heteroatoms or heteroatomic groups independently selected from the group consisting of —N—, —NH—, —O—, and —S—;
• ring B is phenyl or 5- or 6-membered heteroaryl, wherein the 5- or 6-membered heteroaryl contains 1, 2, 3, or 4 heteroatoms or heteroatomic groups independently selected from the group consisting of —N—, —NH—, —O—, and —S—;
• L is —C(Rc)(Rd)—;
• each R1 is independently H, F, Cl, Br, I, CN, C1-6 alkyl, C1-6 heteroalkyl, C(O)OH, NH2, or OH, wherein each C1-6 heteroalkyl contains 1, 2, 3, or 4 heteroatoms or heteroatomic groups independently selected from the group consisting of —N—, —NH—, —O—, and —S—, and further wherein each C1-6 alkyl and C1-6 heteroalkyl is optionally and independently substituted with 1, 2, or 3 independently selected Ra substituents;
• each R2 is independently H, F, Cl, Br, I, CN, C1-6 alkyl, C1-6 heteroalkyl, C(O)OH, NH2, or OH, wherein each C1-6 heteroalkyl contains 1, 2, 3, or 4 heteroatoms or heteroatomic groups independently selected from the group consisting of —N—, —NH—, —O—, and —S—, and further wherein each C1-6 alkyl and C1-6 heteroalkyl is optionally and independently substituted with 1, 2, or 3 independently selected Rb substituents;
• each Ra is independently F, Cl, Br, I, CN, C(O)OH, NH2, or OH;
• each Rb is independently F, Cl, Br, I, CN, C(O)OH, NH2, or OH;
• Rc is H, F, Cl, Br, I, CN, C1-6 alkyl, C1-6 heteroalkyl, C(O)OH, NH2, or OH, wherein the C1-6 heteroalkyl contains 1, 2, 3, or 4 heteroatoms or heteroatomic groups independently selected from the group consisting of —N—, —NH—, —O—, and —S—, and further wherein the C1-6 alkyl or C1-6 heteroalkyl is optionally substituted with 1, 2, or 3 independently selected R substituents;
• Rd is H, F, Cl, Br, I, CN, C1-6 alkyl, C1-6 heteroalkyl, C(O)OH, NH2, or OH, wherein the C1-6 heteroalkyl contains 1, 2, 3, or 4 heteroatoms or heteroatomic groups independently selected from the group consisting of —N—, —NH—, —O—, and —S—, and further wherein the C1-6 alkyl or C1-6 heteroalkyl is optionally substituted with 1, 2, or 3 independently selected R substituents;
• each R is independently F, Cl, Br, I, CN, CH3, C(O)OH, NH2, or OH;
• m is 1, 2, or 3;
• n is 1, 2, or 3;
• and is a single bond or a double bond.