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US 11,230,540 B2Granted
Substituted triazole derivatives and uses thereof
AssigneeBayer Pharma Aktiengesellschaft
InventorsMarie-Pierre Collin-Kroepelin, Peter Kolkhof, Thomas Neubauer, Chantal Fuerstner, Elisabeth Pook, Hanna Tinel, Carsten Schmeck, Pierre Wasnaire, Heiko Schirmer, Klemens Lustig
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Abstract
The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
Claims13
A compound of formula (I)
- in which
- R1 represents hydrogen or methyl,
- R2 represents amino, C1-C5-alkyl, methoxy, cyclopropyl or a 5- or 6-membered heterocyclyl,
- where alkyl may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of fluorine, hydroxy, amino, aminocarbonyl, aminosulfonyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, C3-C6-cycloalkyl, 4- to 7-membered heterocyclyl, methylsulfonyl, methylcarbonylamino, 2,2,2-trifluoroethylaminocarbonyl, methylsulfonylamino and C1-C4-alkoxycarbonyl,
- wherein heterocyclyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of oxo, chlorine, fluorine, hydroxy, formyl, aminocarbonyl, methyl, methoxy, trifluoromethyl, methylcarbonyl, methylsulfonyl and C1-C4-alkoxycarbonyl, and
- wherein cycloalkyl may be substituted by one substituent hydroxyl, and
- where heterocyclyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of oxo, chlorine, fluorine, hydroxy, formyl, aminocarbonyl, methyl, methoxy, trifluoromethyl, methylcarbonyl, methylsulfonyl and C1-C4-alkoxycarbonyl, or
- R1 and R2 together with the nitrogen atom to which they are attached form a 4- to 6-membered heterocyclyl,
- where heterocyclyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of oxo, chlorine, fluorine, hydroxy, aminocarbonyl, methyl, methoxy, trifluoromethyl, methylcarbonyl, methylsulfonyl and C1-C4-alkoxycarbonyl,
- R3 represents phenyl, pyridinyl or 3,3,3-trifluoroprop-1-yl,
- where phenyl may be substituted by one substituent selected from the group consisting of chlorine, fluorine, methoxy and trifluoromethyl, and
- where pyridinyl may be substituted by one substituent selected from the group consisting of chlorine, bromine, fluorine, methoxy, trifluoromethyl and trifluoromethoxy, and/or a pharmaceutically acceptable salt thereof, solvate thereof and/or solvate of a salt thereof.
9 more elements
Dependencies are inferred from the claim text.