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US 11,230,536 B2Granted
Crystalline (2S,4R)-5-(5′-chloro-2′-fluoro-[1,1′-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof
AssigneeTheravance Biopharma R&D IP, LLC
InventorsAdam D. Hughes, Melissa Fleury, Miroslav Rapta, Venkat R. Thalladi
Life of this patent
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Abstract
In one aspect, the invention relates to a crystalline form of the structure: or a pharmaceutically acceptable salt thereof, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this crystalline form; methods of using this crystalline form and its soluble form (I); and processes for preparing soluble (I) and crystalline (I′) forms.
Claims20
A composition comprising a crystalline form of a compound or salt of Formula (I):
Dependencies are inferred from the claim text.