Crystalline salts and polymorphs of a P2X3 antagonist
AssigneeAfferent Pharmaceuticals, Inc.
InventorsPrabha Ibrahim, Ronald Charles Hawley, Anthony P. Ford, Steven A. Smith
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Abstract
Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.
Claims19
A crystalline citrate Form B of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide characterized by having X-ray powder diffraction peaks at 2θ values of approximately 11.3, 16.2 and 23.0 degrees.
A crystalline citrate Form B characterized by having X-ray powder diffraction peaks at 2θ values of approximately 5.7, 8.4, 11.3, 16.2, 18.8, 23.0 and 25.0 degrees.
A crystalline tartrate Form F of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide characterized by having X-ray powder diffraction peaks at 2θ values of approximately 11.3, 18.7, and 22.7 degrees.
Dependencies are inferred from the claim text.