Pyrimidines and variants thereof, and uses therefor

A compound of Formula 1:

• or a pharmaceutically acceptable salt thereof, wherein:
• W is selected from O, S and NH;
• X1 is N or CR2;
• X2 is CR3;
• X3 is CR4;
• X4 is CR5;
• X5 is N or CR6, provided, however, when X1 is CR2, W is not O;
• Y is —NRdRe, wherein one of Rd and Re is hydrogen, and the other is selected from hydrogen and C1-12-alkyl;
• D is absent;
• R1 is selected from C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, C3-12-cycloalkyl, C3-12-cycloalkenyl, C1-12-haloalkyl, and C1-12-hydroxyalkyl;
• R2, R3, and R4 are each independently selected from hydrogen, C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, amino, halo, amido, C1-12-haloalkyl, C1-12-alkoxy, hydroxy, C1-12-haloalkoxy, nitro, C1-12-hydroxyalkyl, C2-12-alkoxyalkyl, C1-12-hydroxyalkoxy, C3-12-alkynylalkoxy, C1-12-alkylsulfonyl, C5-12-arylsulfonyl, cyano, C6-12-aryl, C5-12-heteroaryl, C3-12-heterocyclyl, C4-12-heterocyclylalkoxy, C6-12-aryloxy, C5-12-heteroaryloxy, C7-12-arylalkyloxy, C6-12-heteroaralkyloxy, optionally substituted phenoxy, —(CH2)m—(Z)n—(CO)—Rf and —(CH2)m—(Z)n—SO2—(NRg)n′—Rf, where m, n and n′ are each independently 0 or 1;
• R5 is selected from hydrogen, C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, amino, amido, C1-12-haloalkyl, C1-12-alkoxy, hydroxy, C1-12-haloalkoxy, nitro, C1-12-hydroxyalkyl, C2-12-alkoxyalkyl, C1-12-hydroxyalkoxy, C3-12-alkynylalkoxy, C1-12-alkylsulfonyl, C5-12-arylsulfonyl, cyano, C6-12-aryl, C5-12-heteroaryl, C3-12-heterocyclyl, C4-12-heterocyclylalkoxy, C6-12-aryloxy, C5-12-heteroaryloxy, C7-12-arylalkyloxy, C6-12-heteroaralkyloxy, optionally substituted phenoxy, —(CH2)m—(Z)n—(CO)—Rf and —(CH2)m—(Z)n—SO2—(NRg)n′—Rf, where m, n and n′ are each independently 0 or 1;
• Z is O or NRg;
• Rf is selected from hydrogen, C1-12-alkyl, hydroxy, C1-12-alkoxy, amino, C1-12-hydroxyalkyl and C2-12-alkoxyalkyl;
• each Rg is independently selected from hydrogen and C1-12-alkyl;
• R6 is hydrogen;
• and
• R7 is hydrogen.