Method of preparing 3-fluoroalkyl-1 substituted pyrazol-4-carboxylic acid by air oxidation
AssigneeAba Chemicals Nantong Limited
InventorsZhigang Lin, Yueheng Jiang, Tong Cai
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Abstract
Provided is a method of preparing 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid by air oxidation. The methoduses 3-fluoroalkyl-1-substituted pyrazol-4-formaldehyde as raw material for reaction in a neutral or alkaline condition under the action of a catalyst and with air as an oxidizing agent, to obtain 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid. The method employs a mild, safe and clean reaction, and is suitable for industrial mass production.
Claims4
A method of preparing 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid by air oxidation, wherein 3-fluoroalkyl-1-substituted pyrazol-4-carboxylic acid (Equation II) is obtained with 3-fluoroalkyl-1-substituted pyrazol-4-formaldehyde (Equation I) as raw material for reaction in a neutral or alkaline condition under the action of a catalyst and with the air as an oxidizing agent;
- where, R1 and R2 are hydrogen or fluorine atom;
- R3 is hydrogen atom or lower paraffin hydrocarbon of C1-C4 and X is hydrogen or helium atom;
- wherein said catalyst is nanometer copper oxide.
Dependencies are inferred from the claim text.