Cylcoalkenyl derivatives useful as agonists of the GPR120 and/or GPR40 receptors

A compound of formula (I)

• wherein
• a is an integer from 1 to 3;
• b is an integer from 0 to 2;
• each R0 is independently selected from the group consisting of halogen, oxo, hydroxy, -cyano, C1-4alkyl, fluorinated C1-2alkyl, C1-4alkoxy, and fluorinated C1-2alkoxy;
• R1 is selected from the group consisting of C1-6alkyl, C2-6alkynyl, C3-6cycloalkyl, —(C1-2alkyl)-C3-6cycloalkyl, C5-6cycloalkenyl, bicyclo[3.1.0]hexy-2-yl, (1S,4S)-2-methyl-bicyclo[2.2.1]hept-2-yl, (1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl, 2,2-difluoro-benzo[d][1,3]dioxol-4-yl, phenyl, —(C1-2alkyl)-phenyl, C(O)-phenyl, tetrahydropyranyl, furanyl, pyrimidinyl, pyridyl, thienyl, thiazolyl, —(C1-2alkyl)-thiazolyl, 3,6-dihydro-pyran-4-yl and 1-methyl-imidazol-4-yl;
• wherein the C3-6cycloalkyl or C5-6cycloalkenyl, whether alone or as part of a substituent group is optionally substituted with one or more substituents independently selected from the group consisting of halogen, C1-4alkyl and fluorinated C1-2alkyl;
• and wherein the phenyl, furanyl, pyrimidinyl, pyridyl, thienyl, thiazolyl, or 3,6-dihydro-pyran-4-yl, whether alone or as part of a substituent group is optionally substituted with one or more substituents independently selected from the group consisting of halogen, hydroxy, cyano, C1-4alkyl, fluorinated C1-2alkyl, C1-4alkoxy, fluorinated C1-2alkoxy, —S—(C1-2alkyl), —SO—(C1-2alkyl), —SO2—(C1-2alkyl), nitro, —NRARB, —NH—C(O)—(C1-4alkyl) and phenyl;
• wherein RA and RB are each independently selected from the group consisting of hydrogen and C1-4alkyl;
• R2 is selected from the group consisting of hydrogen, halogen, C1-4alkyl, fluorinated C1-2alkyl, —(C1-4alkyl)-S—(C1-2alkyl), —(C1-4alkyl)-SO—(C1-2alkyl) and —(C1-4alkyl)-SO2—(C1-2alkyl);
• R3 is selected from the group consisting of hydrogen, halogen, C1-4alkyl and fluorinated C1-2alkyl;
• R4 is selected from the group consisting of hydrogen, halogen, C1-4alkyl and fluorinated C1-2alkyl;
• R5 is selected from the group consisting of hydrogen, cyano, halogen, C1-4alkyl, fluorinated C1-2alkyl, vinyl, halogen substituted vinyl, ethynyl, hydroxy substituted C1-2alkyl, C1-4alkoxy, fluorinated C1-2alkoxy, cyclopropyl, cyclopropyl-methyl and phenyl, and
• alternatively, R2 and R5 or R3 and R4 are taken together with the carbon atoms to which they are bound to form cyclopenten-1-yl;
• provided that at least one of R2, R3R4 or R5 is other than hydrogen;
• R6 is selected from the group consisting of hydrogen and methyl;
• or an isotopologue or pharmaceutically acceptable salt thereof.