Evacuated bottle system

A cap assembly configured to removeably attach to a bottle, comprising:

• a self-sealing membrane configured to be inserted into a neck of the bottle and cover a mouth of the bottle while inserted into the neck to selectively seal the interior of the bottle;
• and
• a cap including a cover portion that extends at least partially over the self-sealing membrane, the cover portion includes a central opening and at least one evacuating opening located radially outward of the central opening, wherein the cover portion is axially spaced from the self-sealing membrane to define a gap that permits axial displacement of the self-sealing membrane within the neck of the bottle to selectively open the bottle to fluid communication outside of the bottle, and wherein the cap is configured to removeably attach to the neck of the bottle such that the cover portion extends completely over the mouth of the bottle.

A cap assembly, comprising:

• a serum stopper configured to be positioned within a neck of a bottle, the serum stopper having a first portion and a second portion, the first portion of the serum stopper sized to fit within the neck of the bottle, and the second portion of the serum stopper having a self-sealing membrane that extends radially outwards relative to the first portion and is configured to reside over a mouth of the bottle while the first portion is inside the neck of the bottle;
• and
• a cap having a cap wall sized to receive the serum stopper, wherein the cap includes a cover portion extending radially inward from the cap wall and over the serum stopper, the cover portion includes a central opening and at least one evacuating opening located radially outward of the central opening, wherein the cover portion is axially spaced from the serum stopper to define a gap that permits axial displacement of the serum stopper within the neck of the bottle to selectively open the bottle to fluid communication outside of the bottle, and wherein the cap is configured to removeably attach to the neck of the bottle such that the cover portion extends completely over the mouth of the bottle.