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AssigneeThe University of Memphis Research Foundation
InventorsJoel D. Bumgardner, Chaoxi Wu, Hengjie Su, Tomoko Fujiwara, Daniel G. Abebe, Kwei-Yu Liu, Gregory McGraw, Carlos Lee Bumgardner
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The invention includes chitosan nanofibers having enhanced structural integrity, compositions comprising such chitosan nanofibers, and related methods of use. In a particular aspect, electrospun chitosan nanofibers can be reversibly acylated to enhance structural integrity and promote healing and the formation of tissues in a subject. In another aspect, electrospun chitosan nanofibers comprising at least a portion of the amino groups protected, such as through N-tert-butoxycarbonyl groups, demonstrate enhanced structural integrity and promote healing and the formation of tissues in a subject. The invention also includes compositions and methods for producing a modified chitosan material having anti-inflammatory and pro-healing characteristics and methods of using the modified chitosan materials in a film, a gel, a membrane, microfibers, nanofibers, nano- or micro-particles/spheres and/or sponges. In some aspects, microspheres and methods of producing microspheres comprising modified chitosan are included.
A barrier membrane comprising electrospun chitosan nanofibers, wherein the electrospun chitosan nanofibers are reversibly surface acylated at —OH groups by exposing the electrospun chitosan nanofibers to an acylating catalyst selected from the group consisting of pyridine, 4-dimethylamino-pyridine (DMAP), triethylamine, diisopropylethylamine (DIPEA), lutidine, aluminum chloride, aluminum trifluoride, triphenylphosphine, tributylphosphine, and combinations thereof and an acylating agent selected from the group consisting of a butyric anhydride, acyl chloride, symmetric or mixed acid anhydride, vinyl ester, cyanomethyl ester, S-phenyl thioester, piperidino ester, pyrid-3-yl ester, 4-nitrophenyl ester, 2,4,6-trichlorophenyl ester, 2,3,4,5,6- pentachlorophenyl ester, 2,3,4,5,6-pentafluorophenyl ester, phtalimido ester, succinimido ester, 4-oxo-3,4-dihydrobenzotriazin-3-yl ester, benzotriazolyl ester, and combinations thereof, wherein, during surface acylation, —NH2 groups of the chitosan nanofibers are not acylated.
Dependencies are inferred from the claim text.