Hemostatic compositions and methods of making thereof
AssigneeGuangzhou Bioseal Biotech Co., Ltd.
InventorsShuang Chen, Yufu Li, Dengmin Feng, Xiang Wan
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Abstract
The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated oxidized regenerated cellulose (ORC) fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent; spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate; separating from the substrate and sieving the composition.
Claims2
A powdered hemostatic composition, the composition comprising an agglomerate of at least partially integrated:
- (i) oxidized regenerated cellulose (ORC) fibers,
- (ii) fibrinogen,
- (iii) thrombin, and
- (iv) calcium chloride,
- wherein the agglomerate has a particle size in the range of from about 250 to about 850 microns,
- wherein the ratio of said fibrinogen, thrombin, and calcium chloride to the ORC fibers ranges from 2:1 to 10:1, by weight,
- wherein the agglomerate further comprises a buffering agent, and
- wherein said ORC fibers are not per se neutralized by said buffering agent until the agglomerate is wetted during application and said buffering agent is dissolved.
Dependencies are inferred from the claim text.