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US 11,229,710 B2Granted
Environmentally sensitive compositions comprising a pH-triggered membrane protein and methods of use thereof in the treatment and diagnosis of tumors
AssigneesUniversity of Rhode Island Board of Trustees, Yale University
InventorsYana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
Life of this patent
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Abstract
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
Claims30
An environmentally sensitive composition comprising a pH-triggered membrane peptide comprising
- (a) at least 8 contiguous amino acids of SEQ ID NO:
- 3-11, 14, 18, 19, 21, 24, 25, 31-37, 274, 275, or 283, wherein,
- (b) at least 6 of the contiguous 8 amino acids of said membrane peptide are non-polar,
- (c) at least one of the at least 8 amino acids of said membrane peptide is protonatable, and
- (d) the peptide has a higher affinity to a membrane lipid bilayer at pH 5.0 compared to at pH 8.0, wherein said pH-triggered peptide does not comprise the amino acid sequence of SEQ ID NO:
- 1.
3 more elements
Dependencies are inferred from the claim text.