Poxvirus vectors encoding HIV antigens, and methods of use thereof
AssigneesJanssen Vaccines & Prevention B.V., Bavarian Nordic A/S
InventorsFrank Wegmann, Johannes Petrus Maria Langedijk, Jerôme Hubertina Henricus Victor Custers, Viki Bockstal, Markus Kalla
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Abstract
Poxvirus vectors encoding a synthetic HIV envelope antigen and other HIV antigens, as well as compositions containing such poxvirus vectors and uses of such poxvirus vectors as vaccines to provide improved immunity against HIV, are provided. Also provided are vaccine combinations containing the disclosed poxvirus vectors, adenovirus vectors encoding one or more HIV antigens, and one or more isolated HIV antigenic polypeptides, and methods of using the vaccine combinations to provide improved immunity against HIV.
Claims20
A poxvirus vector comprising nucleic acid encoding:
- (a) a first HIV envelope (Env) antigen comprising the amino acid sequence of SEQ ID NO:
- 18;
- (b) a second HIV Env antigen different from the first HIV Env antigen;
- (c) a third antigen and a fourth antigen, being two different HIV Gag antigens;
- and
- (d) a fifth antigen and a sixth antigen, being two different HIV Pol antigens.
Dependencies are inferred from the claim text.