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US 11,229,692 B2Granted
Methods and compositions for inducing protective immunity against RSV infection
AssigneeJanssen Vaccines & Prevention B.V.
InventorsOlivier Godeaux, Jerald C. Sadoff, Macaya Julie Douoguih
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Abstract
Compositions, vaccines and methods using adenovirus vectors for inducing protective immunity against a respiratory syncytial virus (RSV) infection are described.
Claims14
A vaccine combination comprising:
- (i) a first composition comprising an immunologically effective amount of a first adenovirus vector comprising a nucleic acid encoding an antigenic respiratory syncytial virus (RSV) protein having the amino acid sequence of SEQ ID NO:
- 1 or 2;
- and
- (ii) a second composition comprising an immunologically effective amount of a second adenovirus vector comprising a nucleic acid encoding an antigenic RSV protein having the amino acid sequence of SEQ ID NO:
- 1 or 2,
- wherein one of the compositions is a priming composition and the other composition is a boosting composition.
3 more elements
A method of inducing an immune response against RSV in a subject, the method comprising:
- (i) administering to the subject a first composition comprising an immunologically effective amount of a first adenovirus vector comprising a nucleic acid encoding an antigenic RSV protein;
- and
- (ii) administering to the subject a second composition comprising an immunologically effective amount of a second adenovirus vector comprising a nucleic acid encoding an antigenic RSV protein,
- wherein the adenovirus vector in the first composition (i) comprises a nucleic acid encoding an RSV protein having the amino acid sequence of SEQ ID NO:
- 1 or 2, and the adenovirus vector in the second composition (ii) comprises a nucleic acid encoding an RSV protein having the amino acid sequence of SEQ ID NO:
- 1 or 2.
3 more elements
Dependencies are inferred from the claim text.