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US 11,229,688 B2Granted
Stabilized thrombin
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsYair Pilpel, Sivan Doron, Yuri Zherdev, Tamara Byk-Tennenbaum
Life of this patent
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Abstract
The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
Claims6
A formulation for conversion of fibrinogen to fibrin comprising:
- a thrombin solution comprising thrombin binding oligonucleotide having a molar ratio in the range of 9:1 to about 1:1 thrombin binding oligonucleotide:thrombin, wherein the thrombin concentration is equal to or higher than 4 IU/ml-15,000 IU/ml, and wherein the thrombin binding oligonucleotide is an aptamer of about 14 to about 60 nucleotides in length comprising a nucleic acid sequence selected from SEQ ID NO:
- 1 to SEQ ID NO:
- 6.
Dependencies are inferred from the claim text.