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US 11,229,680 B2Granted
Autophagy inhibitors
AssigneeThe Hong Kong University of Science and Technology
InventorsMingjie Zhang, Jianchao Li, Ruichi Zhu, Chao Wang
Life of this patent
Estimating the term…
Abstract
Provided herein are recombinant peptides useful for inhibiting the function of autophagy-related 8 (Atg8) proteins. The recombinant peptides can be used in the preparation of imaging agents for monitoring autophagy in a cell or subject and treating autophagy related diseases, such as cancer.
Claims17
A recombinant peptide comprising the amino acid sequence of SEQ ID NO:
- 1, wherein position 7, 12, 13 or 16 of SEQ ID NO:
- 1 is substituted with Arg or Gln, and wherein the peptide binds GABA Type A Receptor-Associated Protein (GABARAP).
Dependencies are inferred from the claim text.