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US 11,229,679 B2Granted
Compositions for treating heart disease by inhibiting the action of mAKAPβ
AssigneeAnchored RSK3 Inhibitors, LLC
InventorsMichael S. Kapiloff, Jinliang Li, Michael Kritzer
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Abstract
The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAPβ, or the expression or activity of one or both of those molecules. This composition may be in the form of a peptide that specifically inhibits mAKAPβ binding to RSK3 or in the form of an siRNA construct which inhibits the expression of RSK3.
Claims14
A composition comprising a viral-based gene therapy vector encoding a fragment of an mAKAPβ amino acid sequence,
- wherein said fragment is at least 80% homologous to amino acids 1735-1833 of SEQ ID NO:2 or amino acids 1737-1835 of SEQ ID NO:25, but is not a full-length mAKAPβ, and
- wherein said composition inhibits interaction of RSK3 and mAKAPβ.
Dependencies are inferred from the claim text.