Neuroprotective peptides

A method for promoting the survival of neurons and/or inhibiting neuron death in a patient comprising administering to said patient a pharmaceutical composition comprising an effective amount of a polyarginine peptide having 12 to 18 arginine residues, wherein the pharmaceutical composition does not contain an active pharmaceutical ingredient that is not a poly-arginine peptide, and wherein the patient is an ischemia patient, a perinatal hypoxia-ischemia patient, an Alzheimer's disease patient, a Huntington's Disease patient, a Multiple Sclerosis patient, a Parkinson's disease patient, an amyotrophic lateral sclerosis patient, a stroke patient, a peripheral neuropathy patient, a traumatic brain injury patient, a spinal cord injury patient, or an epilepsy patient.

A method for inhibiting neurological damage from an excitotoxic injury, the method comprising administering to a patient a pharmaceutical composition consisting essentially of:

• (i) one or more peptides with an amino acid sequence consisting of 12 to 18 arginine residues;
• and (ii) one or more pharmaceutically acceptable carriers, adjuvants, or vehicles,
• wherein the patient is an ischemia patient, a perinatal hypoxia-ischemia patient, an Alzheimer's disease patient, a Huntington's Disease patient, a Multiple Sclerosis patient, a Parkinson's disease patient, an amyotrophic lateral sclerosis patient, a stroke patient, a peripheral neuropathy patient, a traumatic brain injury patient, a spinal cord injury patient, or an epilepsy patient.

A method for inhibiting neurological damage from an excitotoxic injury, the method comprising administering to a patient a pharmaceutical composition containing only poly-arginine peptides and one or more pharmaceutically acceptable carriers, adjuvants, or vehicles, wherein the composition includes at least one poly-arginine peptide having a length of 12 to 18 amino acids,

• wherein the patient is an ischemia patient, a perinatal hypoxia-ischemia patient, an Alzheimer's disease patient, a Huntington's Disease patient, a Multiple Sclerosis patient, a Parkinson's disease patient, an amyotrophic lateral sclerosis patient, a stroke patient, a peripheral neuropathy patient, a traumatic brain injury patient, a spinal cord injury patient, or an epilepsy patient.