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US 11,229,677 B2Granted
Antibacterial composition and a method of treating staphylococcal infections with the antibacterial composition
AssigneeIntron Biotechnology, Inc.
InventorsSeong Jun Yoon, Soo Youn Jun, Gi Mo Jung, Sang Hyeon Kang
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Abstract
A method of treating staphylococcal infections includes administering to a subject an effective amount of an antibacterial composition having a broad bactericidal activity. The antibacterial composition includes a first antibacterial protein consisting of the amino acid sequence as set forth in SEQ. ID. NO: 1 and/or a second antibacterial protein consisting of the amino acid sequence as set forth in SEQ. ID. NO: 2.
Claims7
A method of treating staphylococcal infections comprising:
- administering to a subject an effective amount of an antibacterial composition,
- wherein the antibacterial composition has a broad bactericidal activity against all following Staphylococcus species:
- Staphylococcus arlettae, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus carnosus, Staphylococcus carprae, Staphylococcus chromogenes, Staphylococcus cohnii, Staphylococcus delphini, Staphylococcus epidermidis, Staphylococcus equorum, Staphylococcus gallinarum, Staphylococcus hemolyticus, Staphylococcus hominis, Staphylococcus intermedius, Staphylococcus kloosii, Staphylococcus lentus, Staphylococcus lugdunensis, Staphylococcus muscae, Staphylococcus pasteuri, Staphylococcus saprophyticus, Staphylococcus warneri, and Staphylococcus xylosus,
- wherein the antibacterial composition includes a mixture of 15-35 mole % of a first isolated antibacterial protein consisting of the amino acid sequence as set forth in SEQ. ID. NO:
- 1 and 55-85% of a second isolated recombinant antibacterial protein consisting of the amino acid sequence as set forth in SEQ. ID. NO:
- 2;
- and
- wherein the antibacterial composition further includes at least one selected from the group consisting of L-histidine, D-sorbitol, CaCl2, and poloxamer 188.
5 more elements
Dependencies are inferred from the claim text.