Therapeutic peptides for excitatory neurotoxicity-related injuries
AssigneeBiocells (Beijing) Biotech Co., Ltd.
InventorsYing Lu, Huamin Han
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Abstract
There is provided in the present application a peptide comprising the amino acid sequence of YEKLLDTEI (SEQ ID NO: 1) or a functional variant thereof. The peptide is an active peptide for the treatment of a central nervous system injury. The present application also provides a chimeric peptide comprising an active peptide and an internalization peptide. The present application also provides a pharmaceutical composition comprising the active peptide or the chimeric peptide, as well as medical use of the active peptide or the chimeric peptide.
Claims22
A peptide comprising the amino acid sequence YEKLLDTEI (SEQ ID NO:
- 1) or comprising the amino acid sequence identical to YEKLLDTEI (SEQ ID NO:
- 1) except for one or more conservative amino acid substitutions selected from the group consisting of a substitution between D and E, a substitution among L, V and I, and a substitution between T and S, wherein the peptide is capable of binding to the PSD-95/Discs-large/ZO-1 1/2 domain (PDZ1/2 domain) of postsynaptic density 95 protein (PSD-95) and inhibits the interaction between N-methyl-D-aspartic acid receptor (NMDAR) and PSD-95.
Dependencies are inferred from the claim text.