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US 11,229,669 B2Granted
Cells comprising non-HLA restricted T cell receptors
AssigneeMemorial Sloan Kettering Cancer Center
InventorsMichel Sadelain, Jorge A. Mansilla-Soto, Justin Eyquem, Anton Dobrin
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Abstract
The presently disclosed subject matter provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to novel designs of T cell receptors (TCRs) and engineered immunoresponsive cells comprising the same. The novel TCR binds to an antigen in an HLA-independent manner. In certain embodiments, the novel TCR provides enhanced sensitivity for a target gene having a low expression level.
Claims30
An immunoresponsive cell comprising a recombinant T cell receptor (TCR), wherein the recombinant TCR comprises:
- i) a first antigen-binding chain comprising an antigen-binding fragment of a heavy chain variable region (VH) of an antibody;
- and
- ii) a second antigen-binding chain comprising an antigen-binding fragment of a light chain variable region (VL) of the antibody;
- wherein the first and second antigen-binding chains each comprise a TRAC polypeptide or a TRBC polypeptide, wherein at least one of the TRAC polypeptide and the TRBC polypeptide is endogenous, and the first and the second antigen-binding chains bind to an antigen, and the immunoresponsive cell is a cell of lymphoid lineage or a pluripotent stem cell from which a cell of lymphoid lineage may be differentiated.
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Dependencies are inferred from the claim text.