Composition for treating joint disease and kit containing same

A method for treatment of a human joint disease, comprising:

• administering at least three times with a composition containing a modified hyaluronic acid or a pharmaceutically acceptable salt thereof having a group of an anti-inflammatory compound as a sole active ingredient to a joint of a joint disease patient,
• wherein the administration is performed every four weeks or more weeks,
• wherein the composition is suitable for injection,
• wherein the anti-inflammatory compound is diclofenac or a pharmaceutically acceptable salt thereof,
• wherein 30 mg of the modified hyaluronic acid or a pharmaceutically acceptable salt thereof is administered in a single administration,
• wherein the treatment consists of improving and/or suppressing a symptom,
• wherein the modified hyaluronic acid has a structure in which the group of an anti-inflammatory compound is covalently bonded to a hyaluronic acid base skeleton via a spacer of the following Formula (1):
• —NR1—R2—O— (1)
• in Formula (1), R1 is a hydrogen atom;
• and R2 is an ethylene group,
• wherein the hyaluronic acid base skeleton consists of disaccharide units in which N-acetyl-D-glucosamine is linked to D-glucuronic acid by a β-(1,3) bond are linked to each other by a β-(1,4) bond,
• wherein the hyaluronic acid base skeleton and the spacer is bonded by an amide, and
• wherein the spacer and the group of the anti-inflammatory compound is bonded by an ester.