Compound of glycosaminoglycan and its fabrication method as well as application
AssigneeHoly Stone Healthcare Co., Ltd.
InventorHua-Yang Lin
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Abstract
The present invention is related to a compound conjugating a drug with a glycosaminoglycan, such as hyaluronic acid (HA), where the drug is useful for the treatment of diseases such as inflammation, auto-immune disease, allergy, infection and preferably cancer. The conjugated compound of the present invention can increase the concentration of drug at the specific site of disease by an interaction of the glycosaminoglycan used as target drug delivery carrier and the CD44 cell surface receptor, then enhancing the therapeutic efficacy and reducing the systemic side effect of the site-delivered drug.
Claims9
A compound consisting of a conjugate from a hyaluronic acid and gemcitabine, wherein the gemcitabine has an —NH2 group in direct conjugation with a carboxylic group of the hyaluronic acid, its derivative, or a salt thereof wherein the hyaluronic acid has an average molecular weight comprised in the range from 350 kDa to 700 kDa.
Dependencies are inferred from the claim text.