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US 11,229,654 B2Granted
Combination therapy of tetracyclic quinolone analogs for treating cancer
AssigneeSenhwa Biosciences, Inc.
InventorJohn Soong
Life of this patent
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Abstract
The present invention provides methods, compositions, and combinations for treating cancer via combined use of a compound of formula I or a pharmaceutically acceptable salt, ester, solvate and/or prodrug thereof, wherein A, Q, n, m, R7, R8, V, X1, X2, X3, X4, X5, X6, and X7 are as defined herein, and at least one therapeutically active agents selected from immunotherapeutics, anticancer agents, and anti-angiogenics.
Claims13
A method for treating or ameliorating a BRCA1 and/or BRCA2-deficient cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of Compound A:
- or a pharmaceutically acceptable salt thereof, wherein the BRCA1 and/or BRCA2-deficient cancer is selected from the group consisting of breast and ovarian cancer.
Dependencies are inferred from the claim text.