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US 11,229,649 B2Granted
Methods for treating cryptosporidiosis using triazolopyridazines
AssigneeUniversity of Vermont and State Agricultural College
InventorsChristopher D. Huston, Kovi Bessoff, Rajiv Satish Jumani
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Abstract
Methods for treating or prophylaxis of a cryptosporidium infection using compositions comprising a structure disclosed herein. Also provided are pharmaceutical compositions and kits for alleviating the symptoms of, for treating, or for preventing the occurrence of cryptosporidium infection. The kits comprise one or more compounds having a structure disclosed herein, such as in an oral composition, and instructions for use, storage, and the like.
Claims4
A composition comprising a compound having the following structure:
- wherein R4 is selected from the group consisting of hydrogen atom, substituted or unsubstituted C1-C9 alkyl groups, and haloalkyl groups;
- R5 is selected from the group consisting of substituted or unsubstituted benzyl groups, substituted or unsubstituted phenyl groups, substituted or unsubstituted phenoxy groups, and substituted or unsubstituted aniline groups;
- R6 is selected from the group consisting of substituted or unsubstituted C1-C8 alkyl groups, substituted or unsubstituted cycloalkyl groups, substituted or unsubstituted benzyl groups, substituted or unsubstituted phenyl groups, and substituted or unsubstituted heteroaryl groups;
- Y is —CH2C(O)—, wherein the —CH2— of the —CH2C(O)— group is covalently bonded to the asterisked nitrogen of the
- group of structure III;
- X is —CH2—;
- and
- a is 1, wherein the composition is for oral administration and the compound is encapsulated in a pH sensitive polymer suitable for release of the compound in the small intestines, distal small intestine, or colon and.
5 more elements
Dependencies are inferred from the claim text.