US 11,229,642 B2Granted

Composition and method for reducing neutropenia

AssigneeBeyondSpring Pharmaceuticals, Inc.

InventorsLan Huang, George Kenneth Lloyd, Ramon Mohanlal

Life of this patent

Estimating the term…

Disclosed herein are methods of reducing neutropenia that is caused by chemotherapy or radiation therapy by administering plinabulin to a subject.

Dependent claims

A method of reducing neutropenia in a subject, comprising administering plinabulin or a pharmaceutically acceptable salt thereof to the subject,

wherein the neutropenia is induced by administration of a first chemotherapeutic composition comprising one or more chemotherapeutic agents,
wherein the first chemotherapeutic composition comprises one or more agents selected from the group consisting of cyclophosphamide, ifosamide, cisplatin, carboplatin, oxaliplatin, nedaplatin, triplatin tetranitrate, phenanthriplatin, picoplatin, satraplatin, topotecan, doxorubicin, epirubicin, daunorubicin, valrubicin, and pharmaceutically acceptable salts thereof,
or by administration of radiation therapy.

Dependencies are inferred from the claim text.

A61K 31/496
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: non-condensed piperazines…
A61K 31/337
Having oxygen as the only ring hetero atom, e.g. fungichromin: having four-membered rings, e.g. taxol
A61K 31/351
Having six-membered rings with one oxygen as the only ring hetero atom: not condensed with another ring
A61K 31/4745
Ortho- or peri-condensed with heterocyclic ring systems: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines

From the US filing history. Foreign family members aren’t listed.

Loading patent…