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US 11,229,636 B2Granted
Substituted tetrahydroquinolinone compounds as ROR gamma modulators
AssigneeAurigene Discovery Technologies Limited
InventorsRavi Kotrabasaiah Ujjinamatada, Chetan Pandit
Life of this patent
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Abstract
The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder, in particular their use in diseases and/or disorder mediated by RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
Claims41
A compound of formula (I):
- or a pharmaceutically acceptable salt or a stereoisomer thereof;
- wherein,
- ring Het is heterocyclyl;
- each Y1, Y2 and Y3 are independently CRa or N, wherein 0-2 of Y1, Y2 and Y3 are N;
- each Z1, Z2, Z3, Z4 and Z5 are independently CRa or N, wherein 0-3 of Z1, Z2, Z3, Z4 and Z5 are N;
- L is *—NRb—C(O)—(CRbRc)n—, *—C(O)—NRb—(CRbRc)n—, *—NRb—S(O)2—(CRbRc)n— or *—S(O)2—NRb—(CRbRc)n—;
- wherein the group marked with * is connected to the ring containing Y1, Y2 and Y3;
- each R1, R2, R6 and R7 are independently hydrogen, halo, alkyl, hydroxy, hydroxyalkyl, cyano, alkoxy, haloalkyl, haloalkoxy, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, —CORd or —COORd;
- R3 at each occurrence is independently hydroxy, halo, alkyl, alkylamino, alkoxy, haloalkyl, haloalkoxy or cycloalkyl;
- alternatively, two R3 on the same carbon together form an oxo (═O) group;
- R4 is hydrogen, alkyl or alkoxy;
- R5 is alkyl, —(CH2)nNRbRc, hydroxyalkyl, cycloalkyl, aryl or heterocyclyl;
- Ra is hydrogen, alkyl, alkoxy, halo, cycloalkyl or aryl;
- Rb and Rc are each independently hydrogen, alkyl or alkoxyalkyl;
- alternatively, Rb and Rc on the same atom together form a ring;
- Rd is hydrogen, alkyl, alkoxy or cycloalkyl;
- m is 0 to 3;
- and
- n is 0 to 3.
16 more elements
A compound, selected from among:
- Compound
- No.
- IUPAC Name
- 1
- N-(4,6-dimethyl-5-oxo-6-(pyridin-2-yl)-5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-
- (ethylsulfonyl)phenyl)acetamide;
- 2
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridin-3-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 3
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(6-(trifluoromethyl)pyridin-3-
- yl)-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 4
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyridin-2-yl)-7,7-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 5
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-methoxypyridin-2-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 6
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 7
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 8
- N-(6-methyl-5-oxo-6-(5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;
- 9
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 10
- N-(6-(5-chloropyridin-2-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-
- (4-(methylsulfonyl)phenyl)acetamide;
- 11
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-3,6-dimethyl-5-
- oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 12
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridazin-3-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 13
- N-(6-(imidazo[1,2-a]pyridin-8-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(methylsulfonyl)phenyl)acetamide;
- 14
- N-(6-ethyl-6-(imidazo[1,2-a]pyrazin-8-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 15
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(pyrrolo[1,2-a]pyrazin-l-yl)-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 16
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(6-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 17
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridin-3-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 18
- N-(4,6-dimethyl-5-oxo-6-(pyridin-3-yl)-5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-
- (ethylsulfonyl)phenyl)acetamide;
- 19
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 20
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 21
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-methoxypyrimidin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 22
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-methoxypyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 23
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoropyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 24
- N-(6-(5-chloro-3-methoxypyridin-2-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 25
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxypyrimidin-5-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 26
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-4,6-dimethyl-5-
- oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 27
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrazin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 28
- N-(6-(2,6-dimethylpyrimidin-4-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 29
- N-(6-(4,6-dimethylpyrimidin-2-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 30
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxypyrimidin-4-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 31
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 32
- N-(4,6-dimethyl-5-oxo-6-(5-(trifluoromethyl)pyridin-2-yl)-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;
- 33
- N-(6-(imidazo[1,2-a]pyrazin-8-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;
- 34
- N-(4,6-dimethyl-6-(6-methylpyridazin-3-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 35
- N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-
- 2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;
- 36
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(4-hydroxypyrimidin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 37
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-hydroxypyridin-4-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 38
- N-(6-(5-chloro-3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 39
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 40
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-hydroxypyridin-3-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 41
- N-(6-(6-ethylpyridazin-3-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-
- (4-(ethylsulfonyl)phenyl)acetamide;
- 42
- N-(6-(benzo[d][1,3]dioxol-5-yl)-4,6-dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 43
- N-(4,6-dimethyl-6-(1-methyl-1H-benzo[d]imidazol-5-yl)-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 44
- N-(4,6-dimethyl-6-(2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 45
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(5-methylthiophen-2-yl)-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 46
- N-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-
- 2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 47
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(1H-pyrazol-1-yl)-5,6,7,8-
- tetrahydroquinolin-2-yl)acetamide;
- 48
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-6,8-dimethyl-5-
- oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 49
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(3-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 50
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-isopropylpyrimidin-4-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 51
- N-(6-(2,6-dimethylimidazo[1,2-a]pyrazin-8-yl)-6-methyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 52
- N-(4,6-dimethyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 53
- N-(4,6-dimethyl-5-oxo-6-(6-(trifluoromethyl)pyridazin-3-yl)-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 54
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-a]pyrazin-8-yl)-7-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 55
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(6-(trifluoromethyl)pyridazin-
- 3-yl)-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 56
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrimidin-2-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 57
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-isopropoxypyridazin-3-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 58
- 2-(4-(ethylsulfonyl)-2-fluorophenyl)-N-(6-methyl-6-(2-methylimidazo[1,2-
- a]pyrazin-8-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 59
- N-(6-methyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide;
- 60
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-isopropylpyrazin-2-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 61
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrimidin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 62
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-isopropylpyridazin-3-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 63
- N-(6-(6-ethylpyridazin-3-yl)-4,6-dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 64
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxy-6-methylpyrimidin-4-yl)-6-methyl-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 65
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-2-methylpyrimidin-4-yl)-6-methyl-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 66
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoro-2-methylimidazo[1,2-a]pyrazin-8-yl)-
- 6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 67
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methyl-6-(trifluoromethyl)-
- pyrimidin-4-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 68
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(5-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 69
- N-(6-(2,6-dimethylpyrimidin-4-yl)-7,7-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 70
- N-(4,6-dimethyl-6-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 71
- N-(6-(3-cyclopropylimidazo[1,2-a]pyrazin-8-yl)-6-methyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 72
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(2-(trifluoromethyl)-
- imidazo[1,2-a]pyrazin-8-yl)-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 73
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 74
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(3-(trifluoromethyl)-
- imidazo[1,2-a]pyrazin-8-yl)-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 75
- N-(4,6-dimethyl-6-(2-methylimidazo[1,2-b]pyridazin-6-yl)-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 76
- N-(6-(5-cyclopropyl-6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 77
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(imidazo[1,2-b]pyridazin-6-yl)-4,6-dimethyl-5-
- oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 78
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(6-methyl-2-(trifluoromethyl)-
- pyrimidin-4-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 79
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(5-(ethylsulfonyl)pyridin-2-yl)acetamide;
- 80
- 2-(5-(ethylsulfonyl)pyridin-2-yl)-N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-
- oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 81
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6,7-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 82
- N-(6-(2,6-dimethylpyrimidin-4-yl)-7-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 84
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-hydroxypyridin-3-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 85
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 86
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-hydroxy-4-methylpyridin-3-yl)-4,6-dimethyl-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 87
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-7,7-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 88
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 89
- N-(6-(3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(methylsulfonyl)phenyl)acetamide;
- 90
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-hydroxypyridin-2-yl)-7,7-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 91
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-7-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 92
- N-(6-(5-chloroimidazo[1,2-a]pyrazin-8-yl)-6-methyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 93
- N-(6-(6-chloropyridazin-3-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)-2-
- (4-(ethylsulfonyl)phenyl)acetamide;
- 94
- 3-(2-(2-(4-(ethylsulfonyl)phenyl)acetamido)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-6-yl)-6-methoxypyridazine 1-oxide;
- 95
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-4-methylpyridazin-3-yl)-4,6-
- dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 96
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-5-methylpyridazin-3-yl)-4,6-
- dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 97
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoroimidazo[1,2-a]pyrazin-8-yl)-6-methyl-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 98
- N-(6-(6-(dimethylamino)pyridazin-3-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 99
- 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinoline-2-carboxamide;
- 100
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydronaphthalen-
- 2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 101
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-1 of Compound-85);
- 102
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-hydroxypyridin-2-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-2 of Compound-85);
- 103
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- (Isomer-1 of Compound-7);
- 104
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- (Isomer-2 of Compound-7);
- 105
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-1 of Compound-9);
- 106
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-2 of Compound-9);
- 107
- N-(6-(2,6-dimethylpyrimidin-4-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- (Isomer-1 of
- Compound-28);
- 108
- N-(6-(2,6-dimethylpyrimidin-4-yl)-4,6-dimethyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- (Isomer-2 of
- Compound-28);
- 109
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-1 of Compound-31);
- 110
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxypyridazin-3-yl)-4,6-dimethyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-2 of Compound-31);
- 111
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrimidin-2-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-1 of Compound-56);
- 112
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(5-methoxypyrimidin-2-yl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-2 of Compound-56);
- 113
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(3-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-1 of Compound-49);
- 114
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(3-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-2 of Compound-49);
- 115
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-2-methylpyrimidin-4-yl)-6-methyl-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-1 of Compound-65);
- 116
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(6-methoxy-2-methylpyrimidin-4-yl)-6-methyl-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-2 of Compound-65);
- 117
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(6-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-1 of Compound-16);
- 118
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(6-methylimidazo[1,2-a]pyrazin-8-yl)-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-2 of Compound-16);
- 119
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxy-6-methylpyrimidin-4-yl)-6-methyl-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-1 of Compound-64);
- 120
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxy-6-methylpyrimidin-4-yl)-6-methyl-
- 5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- (Isomer-2 of Compound-64);
- 121
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(3-
- (trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl)-5,6,7,8-tetrahydroquinolin-2-
- yl)acetamide;
- (Isomer-1 of Compound-74);
- 122
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-5-oxo-6-(3-
- (trifluoromethyl)imidazo[1,2-a]pyrazin-8-yl)-5,6,7,8-tetrahydroquinolin-2-
- yl)acetamide;
- (Isomer-2 of Compound-74);
- 123
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(5-(ethylsulfonyl)pyridin-2-yl)acetamide;
- (Isomer-1 of Compound-79);
- 124
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(5-(ethylsulfonyl)pyridin-2-yl)acetamide;
- (Isomer-2 of Compound-79);
- 125
- 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinoline-2-carboxamide;
- (Isomer-1 of Compound-99);
- 126
- 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-6-methyl-5-oxo-
- 5,6,7,8-tetrahydroquinoline-2-carboxamide;
- (Isomer-2 of Compound-99);
- 129
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoro-2-methylimidazo[1,2-a]pyrazin-8-yl)-
- 6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 130
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(3-fluoro-2-methylimidazo[1,2-a]pyrazin-8-yl)-
- 6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 131
- N-(6-(6-ethyl-2-methylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 132
- N-(6-(2-ethyl-6-methylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-
- tetrahydroquinolin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 133
- N-(6-(2,6-diethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 135
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-(2-methoxy-6-methylpyrimidin-4-yl)-4,6-
- dimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 136
- N-(7-(2,6-dimethylpyrimidin-4-yl)-7-methyl-8-oxo-5,6,7,8-tetrahydroquinolin-3-
- yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 137
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-
- 2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 138
- N-(6-(2,6-dimethylpyrimidin-4-yl)-6-methyl-5-oxo-5,6,7,8-tetrahydroquinoxalin-
- 2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide;
- 139
- 2-(4-(ethylsulfonyl)phenyl)-N-(6-methyl-6-(2-methyl-6-(trifluoromethoxy)-
- pyrimidin-4-yl)-5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)acetamide;
- 140
- 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-7-isopropyl-5-oxo-
- 5,6,7,8-tetrahydroquinoline-2-carboxamide;
- 141
- 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-8-isopropyl-5-oxo-
- 5,6,7,8-tetrahydroquinoline-2-carboxamide;
- and
- 142
- 6-(2,6-dimethylpyrimidin-4-yl)-N-(4-(ethylsulfonyl)benzyl)-7-isopropyl-6-
- methyl-5-oxo-5,6,7,8-tetrahydroquinoline-2-carboxamide;
- or a pharmaceutically acceptable salt or a stereoisomer thereof.
446 more elements
A compound, having the structure:
- or a pharmaceutically acceptable salt or an enantiomer thereof.
Dependencies are inferred from the claim text.