TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
AssigneeDuke University
InventorWolfgang Liedtke
Life of this patent
Estimating the term…
Abstract
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.
Claims16
A method of reducing periostin release from keratinocytes in a subject in need thereof, the method comprising administering to the subject an effective amount of a TRPV4 and TRPA1 inhibitor, wherein the TRPV4 and TRPA1 inhibitor is according to Formula I:
- wherein A, B, and C are independently selected from aromatic, heteroaromatic, cycloalkenyl, and heterocycloalkenyl groups;
- D is C1-C3 alkylene;
- E is a bond, or C1-C2 alkylene;
- and
- R is selected from hydrogen, hydroxyl, amino, alkyl, alkenyl, heteroalkyl, aromatic ring, or heteroaromatic ring, and
- wherein periostin release from keratinocytes in the subject is inhibited upon administration of the TRPV4 and TRPA1 inhibitor.
A method of reducing periostin release from keratinocytes in a subject in need thereof, the method comprising administering to the subject an effective amount of a TRPV4 and TRPA1 inhibitor, wherein the TRPV4 and TRPA1 inhibitor is according to the below:
- and
- wherein periostin release from keratinocytes in the subject is inhibited upon administration of the TRPV4 and TRPA1 inhibitor.
Dependencies are inferred from the claim text.